Floating bridge tremolo systems have historically caused guitarists as much grief as lead singers. Yet both persist. Fear not though: Seymour Duncan has a set of tips designed to aid and abet your Floyd Rose abuse. The article offers advice on string stretching, string winding, and bridge angle. As they put it:
Following these few simple rules will make your locking tremolo perform like a champ, allowing your guitar to stay in tune even under the most abusive whammy-strangulation.
Read up right here.
And then have a look at Mr. Rose himself right here.